53221 is zip code located in Milwaukee, Wisconsin. The population is 37,707, making 53221 the 5th largest zipcode in Milwaukee and the 5th largest in Milwaukee County.
There are 7 public schools in 53221 with an average Homefacts rating of C. The total crime rate for Milwaukee is high , and there are 72 registered sex offenders residing in the zip code 53221. Unemployment in 53221 is very high.