Clarksville is located in Pike County, MO. The population is 396, making Clarksville the 4th largest city in Pike County.
There are 2 public schools in Clarksville with an average Homefacts rating of B. The total crime rate for Clarksville is high, and there are 4 registered sex offenders residing in the city. Unemployment in Clarksville is low and the median home sales price is $0.