78221 is zip code located in San Antonio, Texas. The population is 36,057.
There are 19 public schools in 78221 with an average Homefacts rating of C-. The total crime rate for San Antonio is high , and there are 96 registered sex offenders residing in the zip code 78221. Unemployment in 78221 is moderate.
Zip codes within San Antonio include 78056, 78152 and 78201.