14221 is zip code located in Buffalo, New York. The population is 52,863, making 14221 the largest zipcode in Buffalo and the largest in Erie County.
There are 1 public schools in 14221 with an average Homefacts rating of A. The total crime rate for Buffalo is high , and there are 11 registered sex offenders residing in the zip code 14221. Unemployment in 14221 is high.