80221 is zip code located in Denver, Colorado. The population is 39,459, making 80221 the 4th largest zipcode in Denver and the 4th largest in Denver County.
There are 18 public schools in 80221 with an average Homefacts rating of D+. The total crime rate for Denver is high , and there are 138 registered sex offenders residing in the zip code 80221. Unemployment in 80221 is moderate.