De Soto is located in Jefferson County, MO. The population is 6,440, making De Soto the 4th largest city in Jefferson County.
There are 6 public schools in De Soto with an average Homefacts rating of C+. The total crime rate for De Soto is very low , and there are 79 registered sex offenders residing in the city. Unemployment in De Soto is low and the median home sales price is $0. Detailed and up-to-date De Soto property reports are available for any property address.